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in the United States, that fraction hovers between 1 in 8 and 1 in 10

Hardeman D, Decroos C, Verhaeghe T, De Smet R, Van der Schueren L, De Baets G, Gallardo R, Rousseau F, Schymkowitz J (2018) Structural characterization of designed aggregation-resistant proteins

Patient Associations: a driving force for Rare Diseases research

18 The greater pharmacodynamic effect of PPIs depends on their ability to block the final step in the production of acid, regardless the secretory stimulus